What we do

To develop portable devices that can be used by both healthcare professionals and consumers to monitor their overall health status via diffuse reflectance spectroscopy(DRS) systems.

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Hardware

We design DRS modules
that can detect
reflected light from skin.

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Programming Console

Software

We develop novel
photon diffusion models to investigate superficial tissues

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What can DRS system do?

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DRS system can accurately calculate the absorption and scattering characteristics of light in tissues and quantify physiological tissue parameters.

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Water

Collagen

Melanin

Hemoglobin

Bilirubin

Blood glucose variation

TLS PATENT Portfolio 

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Publication

  • “Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy”, Chao-Chun Yang, Yun-Yo Yen, Chao-Kai Hsu, Nan-Yu Cheng, Shih-Yu Tzeng, Shih-Jay Chou, Jun-Ming Chang, and Sheng-Hao Tseng*, Scientific Reports, 11, 8901, (2021).

  • “Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion theory-based method”, Nan-Yu Cheng, Yi-Ling Lin, Ming-Chien Fang, Wen-Hsien Lu, Chin-Chieh Yang, and Sheng-Hao Tseng*, Biomedical Optics Express, 10(6), 2969-2984, (2019).

  • “Skin collagen can be accurately quantified through noninvasive optical method: Validation on a swine study”, Shih-Yu Tzeng, Ting-Yung Kuo, Shao-Bu Hu, Yu-Wen Chen, Yi-Ling Lin, Kang-Yu Chu, Sheng-Hao Tseng*, Skin Research and Technology, 00:1-6, (2017).

  • “Light distribution modulated diffuse reflectance spectroscopy”, Pin-Yuan Huang, Chun-Yu Chien, Chia-Rong Sheu, Yu-Wen Chen, and Sheng-Hao Tseng*, Biomedical Optics Express, 7(6), 2118-2129, (2016).

  • “Artificial neural networks for retrieving absorption and reduced scattering spectra from frequency-domain diffuse reflectance spectroscopy at short source-detector separation”, Yu-Wen Chen, Chien-Chih Chen, Po-Jung Huang, and Sheng-Hao Tseng*, Biomedical Optics Express, 7(4), 1496-1510, (2016).​

  • “Portable handheld diffuse reflectance spectroscopy system for clinical evaluation of skin: a pilot study in psoriasis patients”, Shih-Yu Tzeng, Jean-Yan Guo, Chao-Chun Yang, Chao-Kai Hsu, Hung Ji Huang, Shih-Jie Chou, Chi-Hung Hwang, and Sheng-Hao Tseng*, Biomedical Optics Express, 7(2), 616-628, (2016).

  • “Toward reliable retrieval of functional information of papillary dermis using spatially resolved diffuse reflectance spectroscopy”, Yu-Wen Chen , Jun-Yen Guo, Shih-Yu Tzeng, Ting-Chun Chou, Ming-Jen Lin, Lynn Ling-Huei Huang, Chao-Chun Yang, Chao-Kai Hsu, and Sheng-Hao Tseng*, Biomedical Optics Express, 7(2), 542-558, (2016).

  • “Efficient construction of robust artificial neural networks for accurate determination of superficial sample optical properties”, Yu-Wen Chen and Sheng-Hao Tseng*, Biomedical Optics Express, 6(3), 747-760, (2015).

  • “Broadband absorption and reduced scattering spectra of in-vivo skin can be noninvasively determined using δ-P1 approximation based spectral analysis”, Cheng-Hung Hung, Ting-Chun Chou, Chao-Kai Hsu, and Sheng-Hao Tseng*, Biomedical Optics Express, 6(2), 443-456, (2015).

  • “Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy”, Chao-Kai Hsu, Shih-Yu Tzeng, Chao-Chun Yang, Julia Yu-Yun Lee, Lynn Ling-Huei Huang, Wan-Rung Chen, Michael Hughes, Yu-Wen Chen, Yu-Kai Liao, and Sheng-Hao Tseng*, Biomedical Optics Express, 6(2), 390-404, (2015).

  • “A linear gradient line source facilitates the use of diffusion models with high order approximation for efficient, accurate turbid sample optical properties recovery”, Ming-Wei Lee, Cheng-Hung Hung, Jung-Li Liao, Nan-Yu Cheng, Ming-Feng Hou, and Sheng-Hao Tseng*, Biomedical Optics Express, 5(10), 3628-3639, (2014).

  • “Reliable recovery of the optical properties of multi-layer turbid media by iteratively using a layered diffusion model at multiple source-detector separations”, Yu-Kai Liao and Sheng-Hao Tseng*, Biomedical Optics Express, 5(3), 975-989, (2014).

  • “Higher-order modulations of fs laser pulses for GHz frequency domain photon migration system”, Huang-Yi Lin, Nanyu Cheng, Sheng-Hao Tseng, and Ming-Che Chan, Optics Express, 22(4), 3950-3958, (2014).​

  • “Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in-vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study”, Sheng-Hao Tseng*, Chao-Kai Hsu, Julia Yu-Yun Lee, Shih-Yu Tzeng, Wan-Rung Chen, and Yu-Kai Liaw, Journal of Biomedical Optics, 17(7):077005, (2012).

  • “Efficient determination of the epidermal optical properties using a diffusion model–based approach: Monte Carlo studies”, Sheng-Hao Tseng* and Ming-Feng Hou, Journal of Biomedical Optics, 16(8):087007, (2011).

  • “Analysis of a diffusion-model-based approach for efficient quantification of superficial tissue properties”, Sheng-Hao Tseng* and Ming-Feng Hou, Optics Letters, 35(22), 3739-3741, (2010).

  • “Chromophore Concentrations, Absorption and Scattering Properties of Human Skin In-vivo”, Sheng-Hao Tseng*, Paulo Bargo, Anthony Durkin, and Nikiforos Kollias, Optics Express, 17(17), 14599-14617, (2009).

  • “Investigation of a probe design for facilitating the uses of the standard photon diffusion equation at short source-detector separations: Monte Carlo simulations”, Sheng-Hao Tseng*, Carole Hayakawa, Jerome Spanier, and Anthony J. Durkin, Journal of Biomedical Optics, 14(5):054043, (2009).